Srem wine region is located on the slopes of Fruška Gora facing the Danube (north) and Sava (south) rivers. The territory of Srem wine region excludes the peaks of Fruška Gora which are a part of the forest area of the national park. Within Srem region, there is only one sub-region – Fruška Gora. According to 2012 data, there are 2,141 hectares of vineyards in Srem wine region. The vineyards are situated at an altitude ranging from 90 to 270 meters, mainly on the northern and southern slopes. The southern and northern sides of Fruška Gora are intersected by numerous streams that flow into the Danube River to the north and the Sava River to the south. For this reason, exposure of the plot depends on which side of the stream it is located. Smaller or bigger plateaus are nestled between the streams. On the southern slopes of Fruška Gora, these plateaus are spacious, often comprising dozens of hectares in one piece, with gentle sloping and seldom facing erosion problems. The altitude is gradually decreasing as we go from the slopes of Fruška Gora towards the edge of the wine region.

The climate in Šumadija is moderate continental with significant microclimate differences that arise due to the size of the region and the differences in the altitude (from 100m to 1130m). Also, there is an abundance of various micro-locations with features of Župa climate . The winds blow from all directions, but mostly from the west and north-east. The climate is further characterized by moderately warm summers with significant disparities in temperature between day and night. The winters are cold and springs are generally shorter and colder than the autumns. In the north, the effects of the Pannonian steppe-continental climate can be noticed.

In terms of climate, Župa of Aleksandrovac has moderate continental climate with distinctive features of Mediterranean sub-climate. Winters are mild with little snow, and temperatures rarely dropping below -10 degrees C. Therefore, it doesn’t come as a surprise that locals have been involved in vinegrowing for centuries. The driest period of year is April-June, whilst autumn is typically sunny and dry, which is particularly favourable for late varieties such as Prokupac.The moderating factors affecting the local climate are the mountains surrounding the area, including the Kopaonik Mountains (2017m), Željin (1785m) and Jastrebac (1130m) which affect air currents as well as diurnal temperature variations. The area around the rivers affects the microclimate and airflow, and consequently improves the process of photosynthesis, pollination and fertilization.

Climate of the region is defined by the fact that Negotinska Krajina is surrounded from the north and west by mountains, while it opens to the vast plain in the south and east through which air currents arrive from the Black Sea and the Mediterranean. The region has distinct features of continental climate with cold winters and hot summers, when the temperature often reaches 40 degrees in the shade. On the other hand, the snow is a regular occurrence on the territory of eastern Serbia. During the winter, Gornjak and Košava winds are common.